In the first One day international against Pakistan in Multan on Wednesday, West Indies captain Nicholas Pooran won the toss and chose to bat.
The tourists included Romario Shepherd and Rovman Powell in their lineup that defeated the Netherlands in their most recent ODI on Saturday in Amstelveen.
Mohammad Haris, a 21-year-old wicketkeeper-batsman, makes his one-day international debut for Pakistan, while Shadab Khan and Mohammad Nawaz, both spinning all-rounders, return after missing the Australian series in April due to injury.
The three-match series is part of the One-Day Super League, which features ten points per match and qualifies players for the 2023 World Cup.
Pakistan: Babar Azam (captain), Fakhar Zaman, Imam-ul-Haq, Mohammad Haris, Mohammad Rizwan, Khushdil Shah, Mohammad Nawaz, Shadab Khan, Hasan Ali, Shaheen Shah Afridi, Haris Rauf
West Indies: Nicholas Pooran (captain), Shai Hope, Shamarh Brooks, Akeal Hosein, Alzarri Joseph, Brandon King, Kyle Mayers, Rovman Powell, Jayden Seales, Romario Shepherd, Hayden Walsh Junior
Umpires: Aleem Dar (PAK) and Ahsan Raza (PAK) TV umpire: Rashid Riaz (PAK) Match referee: Mohammad Javed (PAK)